ENDOTOXIN BIOSENSOR, NEUTRALIZATION CARTRIDGE AND PROCESSES FOR MANUFACTURING SAME

摘要

The present invention provides an acoustic wave biosensor adapted for the detection of endotoxins and processes for preparing same. The biosensor comprises a piezoelectric substrate modified with a self-assembling monolayer. Immobilized on the self-assembling monolayer is a biochemical probe (preferably, polymyxin B). Such biosensor is functionalized to detect endotoxins utilizing an electromagnetic piezoelectric acoustic sensor. According to another aspect of the present invention, there is provided polymyxin B immobilized beads, processes for preparing same, and neutralization cartridges comprising such beads for the treatment of endotoxemia. Finally, the present invention provide a theranostic circuit device for the treatment of endotoxmeia that utilizes one or more hemoperfusion cartridges and an acoustic wave biosensor.