Provided is an application of gastrodin or gastrodin powder in preparing anti-hepaticfibrosis pharmaceutical. Systematic studies on I-type collagen α1 promoter activity inhibition, ALT and AST content in rat serum, a pathological structure in rat hepatic tissue, hydroxyproline content in rat hepatic tissue, an oxidative stress response in rat hepatic tissue, and influence on degree of rat hepaticfibrosis prove that gastrodin or gastrodin powder has a good anti-hepaticfibrosis activity.
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