METHOD FOR SYNTHESISING PHARMACEUTICAL INTERMEDIATE PHENANTHRENE COMPOUND IN POTASSIUM TERT-BUTOXIDE ENVIRONMENT

摘要

The present invention relates to a method for synthesising a phenanthrene compound as shown in formula (I) in a potassium tert-butoxide environment, the method comprising: reacting the compound of formula (II) with the compound of formula (III) in an inert atmosphere, in the presence of a catalyst, organic ligands and potassium tert-butoxide, and in a solvent, thereby obtaining the compound of formula (I), wherein R₁ and R₂ are each independently H, a C₁-C₆ alkyl group, a C₁-C₆ alkoxy group or a halogen, R₃ is a C₆-C₁₀ aryl group or a C₅-C₈ heteroaryl group, the C₆-C₁₀ aryl group or the C₅-C₈ heteroaryl group being optionally substituted by 1-3 substituents, the substituents being C₁-C₆ alkyl groups or halogens. The method obtains a good effect via the selection of an appropriate catalyst, organic ligands, base and solvent, and has wide prospects for industrial application.