首页> 外国专利> CHLAMYDOMONAS STRAINS WITH CHLOROPLAST-EXPRESSED CRY PROTEINS FOR BIOLOGICAL CONTROL OF MOSQUITOES THAT TRANSMIT DISEASE

CHLAMYDOMONAS STRAINS WITH CHLOROPLAST-EXPRESSED CRY PROTEINS FOR BIOLOGICAL CONTROL OF MOSQUITOES THAT TRANSMIT DISEASE

机译：带有叶绿体表达的晶体蛋白的衣原体菌株，用于生物控制传播疾病的蚊子

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摘要

The present invention relates to producing novel strains of green alga specifically engineered to produce an improved engineered compound over naturally occurring larvicide compound. In particular, genes were isolated and sequenced encoding naturally occurring larvicides produced by Bti (Bacillus thuringiensis subsp. israelensis), e.g. Cry proteins, were redesigned, synthesized, then introduced as heterologous transgenes into strains of Chlamydomonas reinhardtii for producing motile larvicidal -green algae specifically lethal to larvae of mosquitoes and black flies in water systems. Thus green alga (i.e. eukaryote) as motile biocontrol agents are contemplated for use to reduce the number of adult mosquitoes that transmit disease, such as West Nile virus, dengue, encephalitis, and malaria, in addition to reducing the number of adult black flies, in a safe and sustainable manner. 展开▼

机译：本发明涉及产生新的绿藻菌株，所述新的绿藻菌株经特殊工程改造以产生比天然存在的杀幼虫剂化合物改良的工程改造化合物。具体地说，分离并测序了编码由 Bti （苏云金芽孢杆菌亚种israelensis ）产生的天然幼虫的基因。重新设计，合成Cry蛋白，然后将其作为异源转基因导入衣藻（Chlamydomonas reinhardtii）菌株中，以生产能对水系统中的蚊子和黑蝇的幼虫致死的活动性幼虫-绿藻。因此，除了减少成年黑蝇的数量外，绿色藻类（即真核生物）也被认为可用于减少传播疾病（例如西尼罗河病毒，登革热，脑炎和疟疾）的成年蚊子的数量，以安全和可持续的方式。 展开▼

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公开/公告号WO2016179086A2

专利类型

公开/公告日2016-11-10

原文格式PDF

申请/专利权人 BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM;
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申请/专利号WO2016US30401

发明设计人 HERRIN DAVID L.;KANG SEONGJOON;ODOM OBEDD;
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申请日2016-05-02

分类号A01N47/08;A01N63/02;C12N1/13;C12N15/11;

国家 WO

入库时间 2022-08-21 14:15:55

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1. 用于生物控制疾病传播性蚊子的新型副转基因系统 [P] . 中国专利： CN110114462A . 2019-08-09

2. 预防病毒性和衣原体起源的性传播疾病的个人卫生剂 [P] . 中国专利： CN100534422C . 2009.09.02

3. CHLAMYDOMONAS STRAINS WITH CHLOROPLAST-EXPRESSED CRY PROTEINS FOR BIOLOGICAL CONTROL OF MOSQUITOES THAT TRANSMIT DISEASE [P] . 美国专利： US2018312868A1 . 2018-11-01

机译：带有化学表达的叶绿体表达蛋白的衣原体菌株，用于生物控制传播疾病的蚊子

4. CHLAMYDOMONAS STRAINS WITH CHLOROPLAST-EXPRESSED CRY PROTEINS FOR BIOLOGICAL CONTROL OF MOSQUITOES THAT TRANSMIT DISEASE [P] . 世界知识产权组织专利： WO2016179086A3 . 2016-12-15

机译：带有叶绿体表达的晶体蛋白的衣原体菌株，用于生物控制传播疾病的蚊子

5. Chlamydomonas Strains With Chloroplast-Expressed Cry Proteins For Biological Control Of Mosquitoes That Transmit Disease [P] . 美国专利： US2016345590A1 . 2016-12-01

机译：衣藻属菌株与叶绿体表达的Cry蛋白用于生物控制传播疾病的蚊子。

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