CHIMERIC ANTIGEN RECEPTORS WITH CTLA4 SIGNAL TRANSDUCTION DOMAINS

摘要

This disclosure provides chimeric antigen receptors (CAR) having (1) a target binding domain, (2) a hinge region, (3) a transmembrane domain (TM), and (4) an intracellular domain comprising cytotoxic T-lymphocyte associated protein 4 (CTLA4) signal transduction domain or a CTLA4-CD28 signal transduction domain. Also provided are nucleic acid molecules encoding CARs, cells expressing CARs, pharmaceutical compositions and methods of use thereof.