PHARMACEUTICAL COMBINATIONS OF A PI3K INHIBITOR AND A MICROTUBULE DESTABILIZING AGENT

摘要

The present invention relates to the use of (a) 5- (2,6-di-morpholin-4-yl-pyrimidin-4-yl) -4-trifluoromethyl (S) -pyrrolidine-l, 2-dicarboxylic acid 2-amide 1 - ({4-methyl- 5- [2- (2,2,2-trifluoro 4-yl] -thiazol-2-yl} -amide) or a pharmaceutically acceptable salt thereof, and (b) a microtubule destabilizing Combinations comprising topics; A pharmaceutical composition comprising said combination; A method of treating a subject having a tumor disease, comprising administering the combination to a subject in need of treatment for a tumor disease; The use of such a combination for the manufacture of a medicament for the treatment of tumor diseases; And a commercial package therefor.