METHOD OF TREATING DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) USING A BET-BROMODOMAIN INHIBITOR

摘要

The present invention relates to a composition comprising a thienotriazololodiazepine compound represented by the following formula 1 or a pharmaceutically acceptable salt thereof or a hydrate or solvate thereof in a patient having an activated B-cell diffuse large B-cell lymphoma The present invention relates to a method of treating diffuse large B-cell lymphoma comprising the step of administering a pharmaceutically acceptable amount of: Formula 1 R ₁ is alkyl having 1-4 carbon atoms, and R ₂ is a hydrogen atom; A halogen atom; Or alkyl having 1 to 4 carbon atoms optionally substituted by a halogen atom or a hydroxyl group, and R ₃ is a halogen atom; A halogen atom, alkyl having from 1 to 4 carbon atoms, alkoxy having from 1 to 4 carbon atoms, or cyano; _{-NR 5 - (CH 2) m} -R 6, wherein R ₅ is alkyl having a carbon number of 1-4 or a hydrogen atom, m is an integer from 0 to 4, wherein R ₆ is a halogen atom, by an optionally substituted Phenyl or pyridyl; Or -NR ₇ -CO- (CH ₂ ) _n -R ₈ , R ₇ is a hydrogen atom or alkyl having 1-4 carbon atoms, n is an integer of 0-2, and R ₈ is a halogen atom R ₄ is - (CH ₂ ) _a -CO-NH-R ₉ , a is an integer of 1-4, and R ₉ is alkyl having 1-4 carbon atoms; Hydroxyalkyl having 1 to 4 carbon atoms; Alkoxy having 1 to 4 carbon atoms; Or alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, phenyl or pyridyl optionally substituted with an amino or hydroxyl group, or - (CH ₂ ) _b -COOR ₁₀ , b is 1- And R ₁₀ is alkyl having 1-4 carbon atoms.