PREPARATION METHOD FOR (R)-9-2-(PHOSPHONOMETHOXY)PROPYLADENINE WITH HIGH PURITY

摘要

The present invention relates to a method for preparing (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA) with high purity. The method includes easy processing steps and uses, as an intermediate, (diethoxyphosphoryl)methyl naphthalen-2-sulfonate or (diethoxyphosphoryl)methyl naphthalen-2-sulfonate generating little impurities to provide high purity. Thus, it is possible to obtain PMPA with high purity. Particularly, (diethoxyphosphoryl) methyl naphthalen-1-sulfonate is a solid material, is handled with ease during the use for preparation of PMPA, is suitable for mass production, allows production with uniform and constant quality, and thus can be introduced in a precise equivalent amount during the reaction. In addition, the method uses no reagent sensitive to contact with moisture and air, and thus is safe, shows high reproducibility, and is suitable for mass production. Further, PMPA obtained by the method according to the present invention has significantly high purity. Thus, when such PMPA is used, it is possible to obtain tenofovir disoproxil and acid addition salts thereof with high purity, thereby facilitating production of high-quality material medicine.