SINGLE NUCLEOTIDE POLYMORPHISM MARKERS FOR DIAGNOSING AND PREDICTING RHEUMATISM IN EARLY STAGE, AND METHOD FOR GENOTYPING ALLELES SPECIFIC TO RHEUMATISM USING SAME

摘要

Provided are single nucleotide polymorphism (SNP) markers for diagnosing and predicting rheumatism in early stage, and a method for diagnosing and predicting rheumatism in early stage by genotyping alleles specific to rheumatism using the same. The method of the present invention can diagnose and predict rheumatism in early stage by checking and comparing minor allele frequency (MAF) of various candidate SNP markers among a normal group, asymptomatic individuals with autoantibodies, and a rheumatism patient group; and by genotyping alleles specific to rheumatism using selected SNP markers which exhibit statistically significant differences in MAF among the comparative groups.;COPYRIGHT KIPO 2016