首页> 外国专利> A COMPOSITION FOR PREVENTING AND TREATING ACETAMINOPHENINDUCING LIVER INJURY COMPRISING THE PEPTIDE DERIVED FROM PYROPIA YEZOENSIS

A COMPOSITION FOR PREVENTING AND TREATING ACETAMINOPHENINDUCING LIVER INJURY COMPRISING THE PEPTIDE DERIVED FROM PYROPIA YEZOENSIS

机译：预防和治疗乙型肝炎致肝损伤的组合物

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摘要

The present invention relates to a composition for preventing or treating acetaminophen-induced liver damage, containing a peptide which is derived from a protein isolated from laver, as an active ingredient. According to the present invention, the peptide which is composed of amino acid sequences represented by sequence number 1 can stand strong against heat and dryness, different from proteins which are generally susceptible to heat. In addition, the peptide can effectively suppress death of hepatocytes as well as oxidative damage on liver tissues induced by acetaminophen, thereby being useful for preventing or treating liver damage.

机译：本发明涉及一种用于预防或治疗对乙酰氨基酚引起的肝损伤的组合物，该组合物包含作为活性成分的肽，该肽衍生自紫菜分离的蛋白质。根据本发明，与通常易受热的蛋白质不同，由由序列号1表示的氨基酸序列组成的肽可以抵抗热和干燥。另外，该肽可有效抑制肝细胞的死亡以及对乙酰氨基酚引起的肝组织氧化损伤，从而可用于预防或治疗肝损伤。

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公开/公告号KR20160095249A

专利类型
公开/公告日2016-08-11

原文格式PDF
申请/专利权人 PUKYONG NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION;
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申请/专利号KR20150015990
发明设计人 NAM TEAK JEONG;CHOI YOUN HEE;
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申请日2015-02-02
分类号A61K38/16;A23L1/30;A23L1/305;
国家 KR
入库时间 2022-08-21 14:13:46

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11. 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Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - 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