PHARMACEUTICAL COMPOSITION CONTAINING COPTIS JAPONICA MAKINO EXTRACT AS ACTIVE INGREDIENT HAVING ANGIOGENESIS INHIBITION ACTIVITY

摘要

The present invention relates to a pharmaceutical composition including, as an active ingredient, a water extract of Coptis japonica Makino and having an activity of inhibiting angiogenesis to a vascular endothelial growth factor. The water extract of Coptis japonica Makino of the present invention inhibits cell cycle progress by VEGF and makes the cell cycle progress remain at a G1 phase; inhibits proliferation of vascular endothelial cells by the VEGF; inhibits migration of vascular endothelial cells by the VEGF; inhibits microvessel sprouting to the periphery of the artery by the VEGF. Consequently, the angiogenesis inhibiting activity is expressed. Therefore, the present invention may be usefully applied for prevention and treatment of cancer diseases and ocular diseases such as diabetic retinopathy and glaucoma caused by angiogenesis.;COPYRIGHT KIPO 2016