COMPOSITION FOR PREVENTING AND TREATING ORAL DISEASE CONTAINING SILIBININ AS ACTIVE INGREDIENT

摘要

The present invention relates to a composition for preventing and treating an oral disease containing silibinin as an active ingredient. The composition for preventing and treating the oral disease containing silibinin or salt of the silibinin as the active ingredient expresses an excellent antibacterial effect regarding Streptococcus mutans and Porphyromonas gingivalis which are causative bacteria of cavities or periodontitis, suppresses the production of proinflammatory cytokines which brings about the periodontitis, and has an effect capable of suppressing the formation of a bio film on the surface of teeth by the Streptococcus mutans. Therefore, the composition can be usefully used as the composition for preventing and treating the cavities, a bad breath, gingivitis, or the periodontitis. Moreover, the silibinin or the salt of the silibinin has no side effects for a human body as a chemical substance which is derived from plants and thus is safe. Therefore, the composition can be safely applied to a pharmacological or mouthwash composition.;COPYRIGHT KIPO 2016