PLP- PHARMACEUTICAL COMPOSITION COMPRISING ERYTHROCYTES ENCAPSULATING A PLP-DEPENDENT ENZYME AND ITS COFACTOR

摘要

The present invention relates to pharmaceutical compositions containing a PLP-dependent enzyme and optionally a phosphate or non-phosphate precursor thereof, a cofactor, a pyridoxal phosphate (PLP), and / or a PLP Compositions, their use as medicaments, their preparation and their therapeutic treatment. The pharmaceutical compositions comprise erythrocytes and pharmaceutically acceptable excipients that encapsulate the PLP-dependent enzyme. The PLP-dependent enzyme may be methioninease, tyrosine phenol-lyase, tyrosine aminotransferase or cystathionine beta-synthase.