PARAKERATOSIS INHIBITOR PORE SHRINKING AGENT OR AGENT FOR PREVENTING OR IMPROVING ROUGH SKIN AND COMPOSITION FOR EXTERNAL USE ON THE SKIN CONTAINING THE SAME

摘要

The present invention on the safety of such failure abandonment inhibitors, relates to the prevention and rough skin, topical skin improver composition and mixing them shrink pores, have a good effect, sensory stimulation dysfunction inhibitor keratinocytes, and provides a first or rough skin-preventing and improving agents for formulation such as this compound reduced to a skin external composition pores as an active ingredient a compound without problems. The compound is selected from the following general formula (1) or a glutamic acid derivative of the formula 2 and salts thereof. (Formula 1) (in formula 1, a is a carbamoyl group, a benzyloxycarbonyl group, an alkyl group of 1 to 3 carbon atoms, an allyl group or amidino represents an) (formula 2) (in formula 2, Z is an alkyl group of 1 to 4 carbon atoms, having a carbon number of 2-4, such as of alkenyl group; Y is OH, alkyloxy of 1 to 3 carbon atoms, allyloxy groups or NR ₃ R ₄ ; R ₁ ~ R ₄ is a cycloalkyl alkyl group of 1 to 3 carbon atoms, an allyl group, a carbon number of 3-7 alkyl groups, having 3-7 of the cycloalkenyl group, a phenyl group or a benzyl group or a or NR ₁ R ₂ or NR ₃ R ₄ is a heterocyclic Im) ;