T Atopic dermatitis animal model for monitoring T helper cell differentiation and screening method using the same

摘要

The present invention relates to a specific T auxiliary cells (T helper cell) differentiation directional measurement atopic dermatitis animal model for in and how atopic dermatitis regulators screened for screening using the same antigen, a conventional atopic dermatitis NC / Nga mice known as a model animal could not clearly identify the antigen-specific immune response against a specific antigen. However, atopic dermatitis regulators animal model for screening according to the present invention was confirmed that the introduction of the reverse mating the OVA antigen specific transgene (TCR transgen) to the NC / Nga mouse, a T cell having an antigen-specific TCR expression . Therefore, when using T auxiliary cell method differentiation directional screening of animal models and atopic dermatitis control material using the same of the present invention can be clearly analyze the differentiation direction of the T auxiliary cells of a specific immune enhancing agent, may check the effect as atopic dermatitis clearly , can be used to develop more effective atopic dermatitis. ;