12 21 Cell penetrating peptide comprising NP12 polypeptide or NP21 polypeptide derived from human NLBP and cargo delivery system using the same

摘要

The present invention relates to a cell-permeable peptide derived from human NLBP and a cargo delivery system using the same, which comprises: (1) a polypeptide selected from the group consisting of NP1 polypeptide derived from human NLBP and a variant of said NP1 polypeptide; And a second polypeptide group consisting of a human NLBP-derived NP2 polypeptide and a variant of said NP2 polypeptide, and (2) a recombinant cargo fused with said cell membrane transmembrane domain, The method comprising the steps of: The transmembrane domain of the present invention is capable of introducing cargo protein into cells with high efficiency as compared with conventional cell permeable peptides, and is a polypeptide sequence derived from human proteins, And can be usefully used as a signal sequence for transferring a polymer substance into a cell of a human body.