12317-16254 Mitochondrial DNA deletion between about residues 12317-16254 for use in the detection of cancer

摘要

The present invention relates to a method for predicting, diagnosing and monitoring cancer. The method includes obtaining a biological sample, extracting mitochondrial DNA (mtDNA) from the sample, quantifying mitochondrial DNA mutation in the sample, and comparing the level of mtDNA mutation present in the sample with a reference value . The method of the present invention may also be effective in screening for new therapeutic agents and treatment regimens. The method may also be useful for monitoring the response of a subject to prophylactic or therapeutic treatment.