首页> 外国专利> 24-- Novel 24-diaryl-indenopyridine derivatives or pharmaceutically acceptable salts thereof preparation method thereof and pharmaceutical composition containing the same for preventing or treating cancer as active ingredients

24-- Novel 24-diaryl-indenopyridine derivatives or pharmaceutically acceptable salts thereof preparation method thereof and pharmaceutical composition containing the same for preventing or treating cancer as active ingredients

机译:24-新型24-二芳基-茚并吡啶衍生物或其药学上可接受的盐的制备方法和包含其的药物组合物,用于预防或治疗癌症作为活性成分

摘要

The present invention relates to novel 2,4-diaryl-indeno pyridine derivative or a pharmaceutically acceptable salt thereof, their preparation and pharmaceutical compositions for preventing and treating cancer containing the same as an active ingredient relates to, according to the present invention novel 2,4-diaryl inde no-pyridine derivative or a pharmaceutically acceptable salt thereof is the TOPO Topo topoisomerase-I and TOPO- significantly inhibit the activity of, and a variety of human exhibits a high cytotoxicity against a cancer cell line can be useful as preventive and therapeutic agents for cancer. ;
机译:本发明涉及新颖的2,4-二芳基茚基吡啶衍生物或其药学上可接受的盐,其制备和用于预防和治疗含有其作为有效成分的癌症的药物组合物,根据本发明,新颖的2, 4-二芳基茚基无吡啶衍生物或其药学上可接受的盐是TOPO Topo拓扑异构酶-I和TOPO-显着抑制其活性,并且多种对癌细胞系表现出高细胞毒性的人可用作预防和预防癌症的药物。癌症治疗剂。 ;

著录项

  • 公开/公告号KR101646354B1

    专利类型

  • 公开/公告日2016-08-05

    原文格式PDF

  • 申请/专利权人 영남대학교 산학협력단;

    申请/专利号KR20140139645

  • 发明设计人 권영주;이응석;

    申请日2014-10-16

  • 分类号C07D405/14;A61K31/4525;A61P35/00;C07D221/16;C07D405/04;

  • 国家 KR

  • 入库时间 2022-08-21 14:12:07

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