Bordetella pertussis strain for expression of viral neutralizing antigen and immunogenic composition using the same

摘要

The present invention relates to a Bordetella pertussis strain for expressing a virus neutralizing antigen protein and an immunogenic composition using the Bordetella pertussis strain. More particularly, the present invention relates to a Bordetella pertussis strain expressing an influenza virus hemagglutinin in the Fim2 gene, And to a method for producing the Bordetella pertussis strain.As a result of transformation through the Bordetella pertussis strain of the present invention, a killed whole cell vaccine using a strain expressing the neutralizing antigen of the virus as a heterologous antigen protein is expected to be highly effective in utilization, and the Bordetella pertussis strain Of acellular vaccine containing a heterologous antigen protein through the treatment of the chemicals of the present invention. The immunogenic composition comprising the strain does not exhibit infection with Bordetella pertussis when administered in the human body and maintains the function of preventing pertussis, while preventing the virus from expressing a viral-derived heterologous antigen protein that causes neutralizing antibodies It is expected that it can be used as a vaccine or therapeutic strain.;