METHODS FOR THE FORECASTING, DIAGNOSTICS AND TREATMENT OF IDIOPATHIC PULMONARY FIBROSIS

摘要

1. A method for predicting or assisting in predicting idiopathic pulmonary fibrosis (ILF) in a patient, the method comprising obtaining a biological sample from a patient, measuring in a biological sample the expression of one gene or combination of genes or the expression of one protein or combination of proteins encoded by one gene or combination of genes, wherein one gene or combination of genes is selected from any of table 2, table 3, table 4 or table 5, where the increased level of expression of one gene or combination of genes or increased level The lack of expression of a single protein or protein combination is an indicator of the prognosis of a shorter survival time compared to the median survival, and in which a reduced expression level of a single gene or combination of genes or a reduced expression level of a single protein or protein combination is an indicator to predict an increase in survival compared to the median survival. 2. The method of claim 1, wherein one gene or combination of genes, or one protein or combination of proteins is selected from MUCL1, MUC4, MUC20, PRR7, PRR15, SPRR1B, SPRR2D, KRT5, KRT6B, KRT13, KRT14, KRT15, KRT17, SERPINB3, SERPINB4, SERPINB5, SERPINB13, CLCA2, TRPV4, BBS5, MMP3 and SAA4.3. The method of claim 1, wherein one gene or combination of genes is selected from CXCR3, CXCR5, CXCL13, CCR6, CCR7, CD19, CD20 (MS4A1), BLK, BLNK, FCRLA, FCRL2, FCRL5, CD79a, CD79b, CD27, CD28, CD1a, CD1B, CD1C, CD1E, IGHV1-69, IGLJ3, IGJ, IGHV3-48, IGLV3-21, IGKV1-5, IGHG1, IGKC, IGLV6-57, IGK @, IGHA1, IGKV2-24, IGKV1D-8, IGHM .four. The method of claim 1, wherein one gene or combination of genes or one protein or combination of proteins is selected from COL1A1, COL1A2, COL5A2, COL12A1, COL14A1, COL15A1, COL16A1, COL18A1, CTHRC1, HGF, IGFBP7, SCGF (CLEC11); LOXL1, LOXL2; GLI1, Gli2, SMO; SFRP2, DIO2, CDH11, POSTN and TGFB3.5. The method of claim 1, wherein one gene or combination of genes or one protein or combination of proteins is selected from CHI3L1 (YKL-40), CCL11, CCL13, CCL17, CCL18, CXCL13, COMR, MMP3, MMP7, SAA4 (constitutive SAA), POSTN AND SPP1 (OPN) .6. The method of claim 5, wherein one gene or combination of genes or one protein or combination of proteins is selected from MMP3 and SAA4 (constitutive SAA). The method of claim 5, wherein one gene or combination of genes or one protein or combination