Oral delivery system of a protein substance (options), protective shell of a delivery system (options)

摘要

1. The oral drug delivery system of a proteinaceous nature, from liposomes incorporated into particles of a cross-linked natural polysaccharide. 2. The oral delivery system according to claim 1, which provides a halving of the degree of destruction of the active substance of protein nature in the gastric juice within 30 minutes relative to the degree of destruction of the substance of protein nature, encapsulated only in liposomes. 3. The oral delivery system according to claim 1, which provides a 70% reduction in the degree of destruction of the active substance of protein nature in the gastric juice for 30 minutes relative to the degree of destruction of the substance of protein nature encapsulated only in liposomes. 4. The oral delivery system of claim 1, wherein pectin with a low degree of esterification is used to produce particles. The oral delivery system according to claim 4, wherein pectin with an esterification degree of 10-40% is used to obtain particles. 6. The oral delivery system of claim 4, wherein polyvalent metal salts are used for crosslinking. The oral delivery system of claim 6, wherein Saili Al. 8 salts are used for crosslinking. The oral delivery system of claim 7, wherein Ca9 salts are used for crosslinking. The oral delivery system of claim 1, wherein chitosan is used to make particles. The oral delivery system of claim 9, wherein the polyanions are used for crosslinking. The oral delivery system of claim 10, wherein tripolyphosphate is used for crosslinking. The delivery system according to claim 1 in the form of a lyophilisate. 13. Oral drug delivery system of a proteinaceous nature, which provides the release of proteinaceous substances in the intestinal environment. 14. Oral delivery system according to claim 13,