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DERIVATIVES OF STERINS AND THEIR APPLICATION FOR THE TREATMENT OF DISEASES CONNECTED WITH TRANSFORMED ASTROCYTIC CELLS OR FOR THE TREATMENT OF MALIGNANT BLOOD DISEASES
DERIVATIVES OF STERINS AND THEIR APPLICATION FOR THE TREATMENT OF DISEASES CONNECTED WITH TRANSFORMED ASTROCYTIC CELLS OR FOR THE TREATMENT OF MALIGNANT BLOOD DISEASES
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机译:甾体衍生物及其在与转化的星形胶质细胞相关的疾病的治疗或恶性血液病的治疗中的应用
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摘要
1. The compound of formula (I) having the basic structure of 7-beta-hydroxycholesterol, in which - A represents a group - (R), in which R represents an amino acid residue attached to its C-terminus, and n = 1 or 2, wherein R are the same or different, and the N-terminus of said amino acid may be substituted with a —C (O) —R group in which R represents a mono- or polycyclic C-Carylalkyl group, or a mono- or polycyclic C-C heteroarylalkyl group which may contain one or more heteroatoms that may be the same different or different, and which is unsubstituted or substituted by at least one unbranched or branched C-C 1-6 alkyl group; a mono- or polycyclic C-Sarylalkyloxy group or a mono- or polycyclic C-Steroarylalkyloxy group, which may contain one or more heteroatoms, which may be the same or different, which is unsubstituted or substituted by at least one unbranched or branched C-C1-6 alkyl group, or a group - C (O) —NH — R or —C (S) —NH — R wherein R is hydrogen; A C-C1-6 alkyl group, unbranched or branched, unsubstituted or substituted by at least one group selected from OR, NHR and SR, where R is hydrogen, unbranched C-C1-6alkyl or unsubstituted C-Saryl; A C-Saryl group unsubstituted or substituted by at least one unbranched or branched C-C 1-6 alkyl or at least one group selected from OR, NHR and SR, as described above; an acyl group; formyl group; sulfonyl group; sulfinyl group; or R is an allyl group or a sugar residue; a —C (O) —OR group in which R is C-C1-6 alkyl, unbranched
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