risk prediction method development stage III hypertensive disease in hypertensive patients with metabolic syndrome

摘要

A method of predicting the risk of stage III of hypertension in hypertensive patients with the metabolic syndrome, comprising blood sampling, characterized in that from the peripheral venous blood of patients with isolated DNA analyze polymorphisms -308G / A TNFα, + 250A / G Ltα, + 36A / G TNFR1, + 1663A / G TNFR2, and predict an increased risk of stage III hypertension in individuals of Russian nationality, who are natives of the Central Black Soil Region of Russia, in hypertensive patients with metabolic syndrome, in the case of yyavleniya genetic variants with combinations -308A TNFα + 1663G TNFR2 or + 250G Ltα from + 36G TNFR1 or + 250G Ltα with + 1663G TNFR2; a lower risk of developing hypertension stage III disease in individuals of Russian nationality, who are natives of the Central Black Soil Region of Russia, in hypertensive patients with metabolic syndrome, predicted in case of detection of genetic variants of combinations: -308GG TNFα with + 250A Ltα or -308G TNFα with + 250AA Ltα or -308G TNFα with + 250A Ltα.