PHARMACEUTICAL COMPOSITION CONTAINING FIMASARTAN AND HYDROCHLORothIAZIDE

摘要

1. A pharmaceutical composition comprising: fimasartan, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof; hydrochlorothiazide, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a binder having a viscosity of from 20 mPa · s to 1000 mPa · s at 25 ° C.2. The pharmaceutical composition of claim 1, wherein the binder comprises at least one selected from the group consisting of hydroxypropyl cellulose, hydroxypropyl methyl cellulose and polyvinyl pyrrolidone. The pharmaceutical composition according to claim 1, wherein the pharmaceutical composition is characterized by a relative standard deviation (RSD) of 4.0% or less in a content uniformity test. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition is in tablet form. The pharmaceutical composition of claim 4, wherein the tablet comprises an uncoated tablet and a coating layer. The pharmaceutical composition according to claim 5, wherein the uncoated tablet has a crush strength of 7 kP or more. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition is intended to treat hypertension. A method for producing a pharmaceutical composition containing timasartan, a pharmaceutically acceptable salt thereof, its hydrate or solvate thereof and hydrochlorothiazide, a pharmaceutically acceptable salt thereof, its hydrate or solvate thereof, the method comprising the steps of: preparing a mixture containing timasartan, a pharmaceutically acceptable salt thereof, its hydrate or its solvate and hydrochlorothiazide, its pharmaceutically acceptable salt, its hydrate or its solvate; obtaining granules by mixing the mixture with a binder solution in which the binder is dissolved substance possessing