A method of predicting chemosensitivity in patients with lymphoproliferative diseases

摘要

A method of predicting the sensitivity to chemotherapy in patients with lymphoproliferative diseases, comprising determining the serum quantitative levels of markers by analyzing the serum before and after the first cycle of chemotherapy, wherein the serum before chemotherapy determined activity of TK-1 and the concentration of β2-MG and after the first course of chemotherapy Activity TK-1, and if: - the TC-1 activity before treatment 150.0 grandfather / l, the total or partial re is achieved through 6-8 cycles of chemotherapy mission; - level of β2-MG before treatment 2200.0 ug / l, the result of 6-8 chemotherapy courses achieved complete or partial remission; - TC-1 Activity before treatment 150.0 MAE / l and / or β2-MG level before treatment 2200.0 ug / l, the result of 6-8 chemotherapy courses achieved complete or partial remission; - TC-1 activity after one cycle of chemotherapy increases by more than 4-fold relative to the starting value, then by 6-8 cycles of chemotherapy achieved complete or partial remission.