METHOD OF PRODUCING TERPENE α-CHLOROKETONES OR CHLOROHYDROXYKETONES

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to a method of producing novel terpene α-chloroketones or chlorohydroxyketones, which are widely used as intermediates to produce heterocyclic compounds, Darzens condensation epoxides, α-alkyl(aryl)-thiocarbonyl compounds, β-ketoesters. The method includes passing an initial compound through a solution in a solvent, without or in the presence of catalysts, a current of chlorine dioxide gas during a certain period of time, removing the solvent, extraction with diethyl or methyl-tert-butyl ether, washing and drying the reaction mixture over anhydrous MgSO₄, extracting the end product by chromatography on SiO₂ or crystallisation. The initial compound used is isopinocampheol, or neoisoverbanol, or 3β,4β-caranediol.;EFFECT: high output.;3 tbl, 3 ex