METHOD OF TREATING PATIENTS WITH NODULAR AND RADIORESISTANT MALIGNANT TUMOURS

摘要

FIELD: medicine.;SUBSTANCE: photosensitiser Photosens in a dose in 0.3-0.4 mg/kg is administered into the patient once. A first session of a gamma-ray teletherapy covering the tumour is performed 24 hours later in a single boost dose of 3 Gy. A first session of a remote exposure of the tumour and surrounding healthy tissues to laser light at wave length 670 nm is performed 2-3 hours later in a single light dose Ws of 50-100 J/cm² at power density Ps 40-50 mW/cm². That is combined with a session of a contact direct exposure of the tumour to laser light at wave length 670 nm from 2-5 positions depending on a tumour size at a light guide output power P of 100-200 mW and a light dose W of 100 J per each position. The treatment involve 8-10 sessions of the combined gamma-ray teletherapy and photodynamic therapy every 24 hours in the same sequence. That is followed by the gamma-ray teletherapy during 2-4 days.;EFFECT: method makes it possible to: increase the effectiveness of the therapeutic treatment of the patients with nodular and radioresistant malignant tumours; enables reducing a gamma-ray dose with no decline in the therapeutic effect, reduces a total body exposure to gamma-rays due to reducing a total therapeutic dose of the gamma-ray teletherapy, reduces a healthy tissue reaction to ionising radiation within the radiation exposure.;6 ex