首页> 外国专利> METHOD OF TREATING PATIENTS WITH SKIN CANCER WITH NEOPLASTIC PROCESSES INVOLVING SKIN TISSUE, SUCH AS MELANOMA, BASAL CELL AND SQUAMOUS CELL CARCINOMA (VERSIONS)

METHOD OF TREATING PATIENTS WITH SKIN CANCER WITH NEOPLASTIC PROCESSES INVOLVING SKIN TISSUE, SUCH AS MELANOMA, BASAL CELL AND SQUAMOUS CELL CARCINOMA (VERSIONS)

机译:用涉及皮肤组织,如黑色素瘤,基底细胞和鳞状细胞癌的恶性肿瘤过程治疗皮肤癌的方法(版本)

摘要

FIELD: medicine.SUBSTANCE: tumour is sized up on the basis of which intracutaneous injections around an involved tissue prior to or after oncotomy are administered at 2-3 mm from its edge, or directly into a tumour tissue by introducing uniformly a medicinal product presented by 1.0-2.5 ml of a protein-polypeptide complex solution in a pharmaceutically acceptable carrier with the complex content (concentration) of 0.05-0.4 mg, by means of a reverse syringe needle 1-3 times a week, in the form of 6-20 injections within the therapeutic course of 4-14 procedures. The active substance is a protein-polypeptide complex produced of hoofed farm animal's nerve and skin embryonic tissue homogenate and containing negatively charged weak-acid and neutral proteins and polypeptides with molecular weight from 5 to 200 kDa and containing an average molecular weight fraction within 10 to 120 kDa of not less than 80%, with the total protein concentration of 0.2-4.2 mg/ml, the ultraviolet spectrum absorption peak of the solution at wave length 280±5 nm, the UV-visible spectrum peak at wave length 274-284 nm, the presence of specific bands in the range of pl from 4.2 to 8.4 in isoelectric focusing in 5% polyacrylamide gel. What is also presented is a method of treating the patients suffering skin cancer, such as melanoma, basal cell carcinoma, squamous cell carcinoma, wherein the above protein-peptide complex is used in the form of external applications.EFFECT: treating the above skin diseases.10 cl, 2 dwg, 6 ex
机译:技术领域:肿瘤的大小是根据在肿瘤切开术之前或之后围绕受累组织的皮内注射在距其边缘2-3 mm处或通过均匀地引入所呈递的药物直接进入肿瘤组织的基础上确定的通过反向注射器针头,每周1-3次以1.0-2.5 ml蛋白质-多肽复合物溶液的形式,将其在药学上可接受的载体中的复合物含量(浓度)为0.05-0.4 mg,以6-在4-14个疗程的治疗过程中进行20次注射。活性物质是由有蹄动物的神经和皮肤胚胎组织匀浆产生的蛋白质-多肽复合物,含有带负电荷的弱酸和中性蛋白质以及分子量为5至200 kDa的多肽,其平均分子量分数在10至120 kDa不小于80%,总蛋白浓度为0.2-4.2 mg / ml,溶液的紫外光谱吸收峰在波长280±5 nm,紫外可见光谱峰在波长274-284在5%聚丙烯酰胺凝胶中进行等电聚焦时,在4.2-8.4的p1范围内存在特定的带。还提供了一种治疗患有皮肤癌例如黑素瘤,基底细胞癌,鳞状细胞癌的患者的方法,其中上述蛋白质-肽复合物以外用形式使用。效果:治疗上述皮肤病.10 cl,2 dwg,6 ex

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