INACTIVATED EMULSION VACCINE AGAINST FOOT-AND-MOUTH DISEASE TYPES A, O, ASIA-1

摘要

FIELD: veterinary science.;SUBSTANCE: invention relates to veterinary virology and biotechnology and concerns a vaccine containing an active substance and target additives. As the active substance the vaccine contains a mixture of avirulent purified antigen materials of the foot-and-mouth disease (FMD) virus strains A No. 2171/Kabardino-Balkar/2013, A No. 2187/Kuti/2013, Asia-1 No. 1946/Shamir 3/89 and O No. 2123/South Ossetian/2011, obtained in the VNK-21 passaged cell culture representing a suspension primarily containing 146S and 75S immunogenic components of the FMD virus. Besides, the vaccine contains a maintenance medium and an oil adjuvant in effective ratios. As the maintenance medium Earle's solution is used without serum with addition of enzymatic muscular tissue hydrolysate, casein medium albumen hydrolysate and antibiotics at the pH of 7.4-7.6. Of oil adjuvants the vaccine contains the Montanide ISA-70 or Montanide ISA-206 oil adjuvant produced by “Seppic” (France).;EFFECT: vaccine provides protection against the infection agent circulating in Transcaucasus, Central Asia, Middle and Far East regions.;15 cl, 4 dwg, 8 tbl, 9 ex