METHOD FOR TUMOUR GROWTH INHIBITION IN EXPERIMENT

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine, specifically to immunology, cell biotechnologies, and can be used for recovery of anti-tumour immunity and tumour growth inhibition with further application in the clinical practice. Disclosed is a method for tumour growth inhibition in experiment, which comprises using macrophages with blocking anti-inflammatory transcription factors STAT3 and STAT6, wherein before blocking anti-inflammatory transcription factors STAT3 and STAT6, macrophages are being exposed with the serum-free medium, then with cytokine IFN-γ in the concentration of 20 ng/ml.;EFFECT: technical result is forming macrophages with M3 phenotype, or selection phenotype possessing the effective anti-tumour mechanisms, resistant to reprogramming tumour effects.;1 cl, 3 dwg, 6 tbl