SIMULATION OF PROPAGATION OF PHARMACEUTICAL PREPARATION AND GENERATION OF PARAMETERS FOR INJECTION PROTOCOLS

摘要

FIELD: medicine.;SUBSTANCE: group of inventions refers to medicine and can be used for simulation of propagation of a contrast agent in a patient. For this purpose a physiologically proved pharmacokinetic model is used containing one nonlinear period of saturation in the peripheral venous compartment. Herewith the exogenous administration of the contrast agent is determined by the non-linear input function u_exog(t)≡=C_inj(t)·Q_inj(t), where C_inj(t) is the concentration of the contrast enhancing agent as a function of time and Q_inj(t) is the flow rate of the contrast agent administration as a function of time, herewith Q_inj(t) is a constant equal to the specified maximum administration flow rate having flow rates of administration equal to or greater than the specified maximum administration flow rate. Also proposed is a system for simulation of the contrast agent propagation.;EFFECT: group of inventions enables eliminating undesirable side effects associated with excessive administration of a contrast agent into a patient.;19 cl, 17 tbl, 47 dwg