USE OF INVERSE AGONISTS OR ANTAGONISTS OF GHRELIN RECEPTOR FOR TREATING SLEEP DISORDERS

摘要

FIELD: medicine.;SUBSTANCE: group of inventions relates to medicine, specifically to neurology, and can be used for treating primary sleep disorder. Patient is administered a therapeutically effective amount of (R)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3,5]nonan-7-yl)ethanone or its pharmaceutically acceptable salt or a pharmaceutical composition containing therapeutically effective amount of (R)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3,5]nonan-7-yl)ethanone or its pharmaceutically acceptable salt and at least one pharmaceutically acceptable carrier, diluent or excipient.;EFFECT: group of inventions provides earlier sleep start time and considerable increase of its duration, as well as reduction of appetite.;4 cl, 6 dwg, 2 tbl