A method for the detection of toxins, and / or pyrogenic by means of changes in the protein expression in ciliates of the genus tetrahymena

摘要

A method for the detection of toxins, and / or pyrogenic, characterized in that hybridoma cells of the genus tetrahymena are incubated with a sample and then is investigated whether it in the case of the treated ciliates to a change in the expression and / or release of one or more of endogenous proteins has occurred, wherein the endogenous proteins are selected from tnf - alpha, ifnγ - γ, il - 1alpha, il - 1beta, il - 6, il - 2, il - 3, il - 8, the / mcp - 1, kc, ip - 10, mip - 1alpha, mip - 1beta, hdc, cox - 1, inos and / or growth factors.