Reduction of deallylation of naloxone during storage of a naloxone-containing sustained-release formulation

摘要

A packaged pharmaceutical composition comprising a) a sustained release pharmaceutical formulation, wherein the sustained release pharmaceutical formulation comprises naloxone or a pharmaceutically acceptable salt thereof, oxycodone or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable sustained release sustained release agent of the naloxone or pharmaceutically acceptable salt thereof, and b ) a package, wherein the package is a blister pack comprising a mold sheet and a cover sheet, wherein the mold sheet and cover sheet independently have a water vapor permeability of ≤ 3.0 g / (m 2 · d).