METHOD FOR THE PREPARATION OF REACTIVE 18F FLUORIDE

摘要

The present invention is related to a method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step, said extraction, concentration and/or reformulation process comprising a steps of passing said aqueous [18F] fluoride solution through a solid phase extraction column containing a modified non-ionic solid support (SS) so that that said [18F] fluorides are trapped on the solid support. The modification of the non-ionic SS has been performed prior to the [18F] fluoride extraction process, by causing the adsorption of a trapping agent (TA) on the SS, said TA being selected for its ability to trap the (18F) fluoride in an anion exchange process so that to form a TA-[18F] species, itself able to remain adsorbed on the SS, the couple SS-TA being selected in such a way that most of the TA is able to remain on the SS during the transit of the aqueous [18F] fluoride solution through the column.