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SELF-ASSEMBLED COMPOSITE ULTRASMALL PEPTIDE-POLYMER HYDROGELS

机译:自组装复合超小肽-聚合物水合物

摘要

The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z—(X)m—(Y)n—Z′p, wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z′ is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.
机译:本发明涉及复合水凝胶,其包含至少一种非肽聚合物和至少一种具有通式:Z-(X)m-(Y)n-Z'p的肽,其中Z是N-末端保护基;在每次出现时,X独立地选自脂族氨基酸,脂族氨基酸衍生物和甘氨酸;在每次出现时,Y独立地选自极性氨基酸和极性氨基酸衍生物; Z'为C端保护基; m为2〜6的整数。 n选自1或2;并且p选自0或1。本发明进一步涉及生产复合水凝胶的方法,涉及该复合水凝胶在递送药物和其他生物活性剂/部分中的用途,作为有助于组织再生的植入物或注射剂。 ,并作为伤口愈合的外用剂。本发明进一步涉及包含复合水凝胶的装置和药物或化妆品组合物,并且涉及该复合水凝胶的医学用途。

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