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NEW THERAPEUTIC AGENT FOR MALIGNANT MESOTHELIOMA AND IMMUNOSTIMULANT
NEW THERAPEUTIC AGENT FOR MALIGNANT MESOTHELIOMA AND IMMUNOSTIMULANT
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机译:恶性间皮瘤和免疫抑制剂的新型治疗剂
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摘要
According to the present invention, a method for treating malignant mesothelioma using REIC/Dkk-3 and a therapeutic agent for malignant mesothelioma comprising REIC/Dkk-3 are provided. A mesothelioma therapeutic agent is provided, comprising the following REIC/Dkk-3 DNA or a vector comprising the DNA as an active ingredient: (a) a DNA consisting of the nucleotide sequence shown in SEQ ID NO: 1; or (b) a DNA hybridizing under stringent conditions to a DNA consisting of a nucleotide sequence complementary to the nucleotide sequence shown in SEQ ID NO: 1 and encoding a protein having apoptosis-inducing activity and IL-7 production-accelerating activity in cells.
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机译:根据本发明,提供了使用REIC / Dkk-3治疗恶性间皮瘤的方法和包含REIC / Dkk-3的恶性间皮瘤治疗剂。提供了一种间皮瘤治疗剂,其包含以下REIC / Dkk-3 DNA或包含该DNA作为活性成分的载体:(a)由SEQ ID NO:1所示核苷酸序列组成的DNA;要么(b)在严格条件下与由与SEQ ID NO:1所示的核苷酸序列互补的核苷酸序列组成的DNA杂交的DNA,该DNA编码在细胞中具有凋亡诱导活性和IL-7产生促进活性的蛋白质。
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