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Cells coexpressing vitamin K reductase and vitamin K dependent protein and use thereof to improve the productivity of said vitamin K dependent protein
Cells coexpressing vitamin K reductase and vitamin K dependent protein and use thereof to improve the productivity of said vitamin K dependent protein
The present invention provides a host cell comprising a heterologous nucleic acid encoding a vitamin K epoxide reductase (VKOR) and a nucleic acid encoding a vitamin K dependent protein, wherein the nucleic acids encoding both the VKOR and Vitamin K dependent protein are expressed in said host cell. The invention also provides methods for improving the productivity of vitamin K dependent protein expression in a host cell.
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