首页>
外国专利>
TRANSGENIC ANIMALS CAPABLE OF PRODUCING HUMANIZED IGE AT MUCH HIGHER LEVELS THAN MOUSE IGE
TRANSGENIC ANIMALS CAPABLE OF PRODUCING HUMANIZED IGE AT MUCH HIGHER LEVELS THAN MOUSE IGE
展开▼
机译:能够产生比小鼠IGE高得多水平的人为IGE的转基因动物
展开▼
页面导航
摘要
著录项
相似文献
摘要
The transgenic non-human animals are constructed, in whose genome the coding sequences of one of the animal's endogenous immunoglobulin Cγ constant regions are replaced by human immunoglobulin Cε constant region coding sequences. The transgenic animal is mouse, in whose genome the Cγ1 constant regions are replaced by the human immunoglobulin Cε constant regions and the Cκ constant region is replaced by the human immunoglobulin Cκ constant region. The transgenic mouse yields humanized IgE-secreting B cells and antigen-specific humanized IgE after immunization. The transgenic animals are employed to prepare serum containing humanized IgE, antiserum containing antigen-specific humanized IgE, and monoclonal antigen-specific humanized IgE antibodies by hybridoma and other technologies.
展开▼