首页> 外国专利> PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT AND PHARMACEUTICAL PREPARATION FOR CANCER TREATMENT CONTAINING SAME COMPOSITION AS ACTIVE INGREDIENT

PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT AND PHARMACEUTICAL PREPARATION FOR CANCER TREATMENT CONTAINING SAME COMPOSITION AS ACTIVE INGREDIENT

机译:包含相同成分作为有效成分的癌症药物制剂和药物治疗制剂

摘要

The purpose of the present invention is to provide a novel anticancer therapeutic having a high effect against solid cancers, lacking the side effects of chemotherapeutics, and being unlikely to cause resistance. Provided is a pharmaceutical composition for cancer treatment prepared by a method having: a stem cell production step for making immortalized stem cells by introducing four types of genes into deciduous tooth dental pulp stem cells obtained from the dental pulp of mammals; and a condition medium preparation step for culturing the immortalized stem cells for a predetermined length of time in serum-free medium at 23-27°C under conditions of low oxygen concentration at an oxygen concentration of from 0.5% to less than 20%, the pharmaceutical composition containing 1.5 times or more of insulin-like growth factor (IGF-1) and vascular endothelial growth factor (VEGF) than is contained in condition medium prepared when culturing at an oxygen concentration of 20% and otherwise identical conditions.
机译:本发明的目的是提供一种新型的抗癌治疗剂,其对实体癌具有很高的作用,没有化学疗法的副作用,并且不太可能引起耐药性。本发明提供一种用于癌症治疗的药物组合物,其通过以下方法制备:干细胞生产步骤,其通过将四种类型的基因导入从哺乳动物的牙髓获得的乳牙牙髓干细胞中来制备永生化的干细胞;和以及条件培养基制备步骤,其在低氧浓度,氧浓度为0.5%至小于20%的条件下,在无血清培养基中于23-27℃下将永生化的干细胞培养预定的时间,该药物组合物含有的胰岛素样生长因子(IGF-1)和血管内皮生长因子(VEGF)的含量是在20%氧气浓度和其他相同条件下培养的条件培养基中所含含量的1.5倍或更多倍。

著录项

  • 公开/公告号EP3093023A4

    专利类型

  • 公开/公告日2017-10-11

    原文格式PDF

  • 申请/专利权人 QUARRYMEN & CO. INC.;

    申请/专利号EP20150740157

  • 发明设计人 UEDA MINORU;

    申请日2015-01-23

  • 分类号A61K35/32;A61P35;A61K38/30;A61K38/19;A61K38/18;

  • 国家 EP

  • 入库时间 2022-08-21 14:06:52

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