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E. COLI MEDIATED siRNA SILENCING OF AVIAN INFLUENZA IN CHICKENS
E. COLI MEDIATED siRNA SILENCING OF AVIAN INFLUENZA IN CHICKENS
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机译:大肠杆菌介导的小鸡禽流感siRNA沉默
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摘要
Products and associated methods are described for the delivery of one or more small interfering RNAs (siRNAs) to an avian cell using a nonpathogenic bacterium for the prevention or treatment of Avian Influenza Virus (AIV). The siRNA is complementary to an mRNA of the AIV NP or PA sequence. In challenge studies with chickens, the siRNA is shown to prevent the onset of clinical symptoms or reduce the severity of disease, including reducing viral titers or virus shedding.
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