HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS AND RADIOLIGANDS AS PROBES IN NOCICEPTIVE PROCESSING AND THE PATHPHYSIOLOGICAL STUDY OF MEMORY DEFICITS AND CONITIVE DISORDERS

摘要

Compound III ' or IV ' with general formula;The ring-type or non-cyclic tertiary amine or isoindoline-1,3- diketone that the heterocycle or group that C-4 to the C-7 that wherein R1 can be that group optionally replaces contains nitrogen optionally replace: R2,4,5,6 can be independently respectively the following part of any one or combination, cyano; nitro, acyl group, alkyl; amino, azido, isothiocyanates; isocyanates, the anilino- optionally replaced, halogen, ether; sulfonamide, Thioacyl, nitro, aromatic series, heterocycle, alkene, acetylene; deuterium, tritium; Y is S; Z can be or H, O, S, S-R or NR groups, and R is H, aryl, alkyl or naphthenic base here; " receiving n items " can be 1 to 5 carbon length and stereoisomer, functional analogue, and its pharmaceutically acceptable salt, wherein bridge joint R1 and N in the part can be substituted alkylene, the alkenylene optionally replaced or the alkynylene optionally replaced may include insertion C3-C5 naphthenic base in alkylidene, aryl and heterocycle; Wherein X is C1-C4 radiohaloalkyl.