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C5-C6 OXACYCLIC-FUSED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
C5-C6 OXACYCLIC-FUSED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
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机译:C5-C6氧杂噻嗪类二氧化物化合物作为抑制剂,组合物及其用途
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摘要
In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomers and said stereoisomers, wherein each of ring A, ring B, ring C, R2, R3, R4, m, n, p, and -L1- is as defined herein. The novel compounds of the invention may be useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including Alzheimer's disease, are also disclosed.
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机译:在其许多实施方案中,本发明提供了某些亚氨基二氮杂二嗪化合物,包括化合物式及其互变异构体和立体异构体,以及所述化合物,所述互变异构体和所述立体异构体的药学上可接受的盐,其中每个环A,环B,环C,R 2 R 3,R 4,m,n,p和-L 1-如本文所定义。本发明的新型化合物可用作BACE抑制剂和/或用于治疗和预防与其有关的各种病理。还公开了包含一种或多种此类化合物(单独或与一种或多种其他活性剂组合)的药物组合物,以及其制备和使用方法,包括阿尔茨海默氏病。
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