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COMPOSITION CONTAINING ACTIVE COMPONENTS OF DRACOCEPHALUM MOLDAVICA L. AGAINST MYOCARDIAL ISCHEMIA-REPERFUSION INJURY

机译：含有Dracocephalum mouldavica L.活性成分的组合物，用于抗心肌缺血再灌注损伤

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摘要

Disclosed is a composition containing active components of Dracocephalum moldavica L. against myocardial ischemia-reperfusion injury (MIRI). The composition consists of active components and a pharmaceutically acceptable carrier, wherein the active components comprise luteolin, kaempferol and luteolin-7-0-glucoside. Pharmacodynamic experiments show that these three components can be combined together to synergistically treat myocardial ischemia-reperfusion injury.

机译：公开了一种组合物，其包含 Dracocephalummoldavica L。的抗心肌缺血-再灌注损伤（MIRI）的活性成分。该组合物由活性成分和药学上可接受的载体组成，其中活性成分包括木犀草素，山奈酚和木犀草素-7-0-葡糖苷。药效实验表明，这三种成分可以组合在一起，以协同治疗心肌缺血-再灌注损伤。 展开▼

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公开/公告号EP3228316A1

专利类型

公开/公告日2017-10-11

原文格式PDF

申请/专利权人 NANJING RUIYING RUNZE BIOPHARMACEUTICAL TECHNOLOGY CO. INC.;
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申请/专利号EP20150866026

发明设计人 SHANG JING;YU DONGSHENG;TIAN YOUQING;WU HUALI;DING LIN;LIU JUN;
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申请日2015-03-06

分类号A61K31/7048;A61P9/10;A61K31/352;A61P9/06;A61P9;

国家 EP

入库时间 2022-08-21 14:05:54

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3. Composition containing active components of Dracocephalum moldavica L. against myocardial ischemia-reperfusion injury [P] . 美国专利： US10369165B2 . 2019-08-06

机译：包含 Dracocephalum Moldavica L活性成分的组合物。对抗心肌缺血再灌注损伤

4. COMPOSITION CONTAINING ACTIVE COMPONENTS OF DRACOCEPHALUM MOLDAVICA L. AGAINST MYOCARDIAL ISCHEMIA-REPERFUSION INJURY [P] . 欧洲知识产权局专利： EP3228316A4 . 2018-04-25

机译：含有Dracocephalum mouldavica L.活性成分的组合物，用于抗心肌缺血再灌注损伤

5. Composition Containing Active Components Of Dracocephalum Moldavica L. Against Myocardial Ischemia-Reperfusion Injury [P] . 美国专利： US2017266216A1 . 2017-09-21

机译：包含头孢霉菌抗心肌缺血-再灌注损伤的活性成分的组合物

1. Effect of dexmedetomidine on monophasic action potential amplitude in myocardial ischemia-reperfusion and its correlation with myocardial injury [J] . Ming-Min Jiang, Li Xiong 海南医科大学学报（英文版） . 2018,第012期

2. Effect of dexmedetomidine on monophasic action potential amplitude in myocardial ischemia-reperfusion and its correlation with myocardial injury [J] . Ming-Min Jiang, Li Xiong 海南医科大学学报(英文版) . 2018,第012期

3. Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats [J] . Xiaozheng Zhong, Qing Yang, Qi Chen, 生物医学研究杂志（英文版） . 2012,第005期

4. Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats [J] . Xiaozheng Zhong, Xiaoyu Li, Lingling Qiana, 生物医学研究杂志：英文版 . 2012,第005期

5. Influences of ischemic postconditioning at different positions on oxidative stress of myocardial ischemia-reperfusion injury in rats [J] . Chao Wang, Jian An, Xiao-Hong Li, 海南医科大学学报(英文版) . 2021,第006期

6. Development of solid lipid nanoparticles containing total flavonoid extract from Dracocephalum moldavica L. and their therapeutic effect against myocardial ischemia–reperfusion injury in rats [J] . Mei-e Tan, Cheng-hui He, Wen Jiang, International Journal of Nanomedicine . 2017,第6期

7. Antioxidative and cardioprotective effects of total flavonoids extracted from Dracocephalum moldavica L. against acute ischemia/reperfusion-induced myocardial injury in isolated rat heart. [J] . Jiangtao Jiang, Xuan Yuan, Ting Wang, Cardiovascular toxicology . 2014,第1期

8. Protective Effects of Total Flavonoids from Dracocephalum moldavica L. on Myocardial Ischemia / Reperfusion Injury in the Isolate Rats Heart [J] . Yu Bacui, Wang Ting, Zhang Bo, Journal of Pure & Applied Microbiology . 2013,第Speca1期

9. Cardio-Protective Effects of Total Flavonoids from Dracocephalum moldavica L. on Acute Myocardial Ischemia/Reperfusion Injury in Rats [C] . Wang Ting, Dong Wang, Fu Wei, 5th International Conference on Bioinformatics and Biomedical Engineering . 2011

10. Myocardial ischemia-reperfusion injury: Development of a new mathematical model and application to investigations of arrhythmogenesis and therapeutic alternatives. [D] . Roberts, Byron Neil. 2012

11. Development of solid lipid nanoparticles containing total flavonoid extract from Dracocephalum moldavica L. and their therapeutic effect against myocardial ischemia–reperfusion injury in rats [O] . Mei-e Tan, Cheng-hui He, Wen Jiang, 2017

12. The Mechanism Study of Dracocephalum Moldavica L. Total Flavonoids on Apoptosis induced by Myocardial Ischemia/Reperfusion injury in vivo and in vitro [O] . Xinchun Wang 2019

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