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MODIFIED VASCULAR ENDOTHELIAL GROWTH FACTOR A (VEGF-A) AND ITS MEDICAL USE
MODIFIED VASCULAR ENDOTHELIAL GROWTH FACTOR A (VEGF-A) AND ITS MEDICAL USE
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机译：改良的血管内皮生长因子A（VEGF-A）及其医学用途
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摘要
The present invention relates to a modified vascular endothelial growth factor A (VEGF-A) polypeptide, particularly to a modified VEGF-A 121 isoform for use in treating an angiogenic disorder. The modified vascular endothelial growth factor A (VEGF-A) comprises a hydrophobic amino acid in place of the lysine at the position corresponding to position 84 of the wild-type VEGF-A as shown in SEQ ID NO: 2, and/or the modified vascular endothelial growth factor A (VEGF-A) comprises a hydrophobic amino acid in place of the phenylalanine at the position corresponding to position 17 of the wild-type VEGF-A as shown in SEQ ID NO: 2.
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机译：本发明涉及修饰的血管内皮生长因子A（VEGF-A）多肽，尤其涉及用于治疗血管生成性疾病的修饰的VEGF-A 121同工型。修饰的血管内皮生长因子A（VEGF-A）在对应于野生型VEGF-A的84位的位置上包含取代赖氨酸的疏水氨基酸，如SEQ ID NO：2所示，和/或修饰的血管内皮生长因子A（VEGF-A）在对应于野生型VEGF-A位置17的位置包含疏水性氨基酸代替苯丙氨酸，如SEQ ID NO：2所示。
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