首页> 外国专利> A PROCESS FOR PREPARATION OF BIOAVAILABLE WHITE CURCUMIN - A UNIQUE BLEND OF HYDROGENATED CURCUMINOIDS

A PROCESS FOR PREPARATION OF BIOAVAILABLE WHITE CURCUMIN - A UNIQUE BLEND OF HYDROGENATED CURCUMINOIDS

机译:一种可生物利用的白姜黄素的制备方法-一种独特的加氢姜黄素混合物

摘要

The present invention discloses a process for preparation of white curcumin from purified curcuminoids. The curcuminoids are obtained by solvent extraction and crystallization of dried turmeric powder. The autoclave is charged with ethyl acetate and the 95% purity curcuminoids mixture is added to and stirred for uniformity at room temperature. 5% (w/w) of 10% palladium carbon is added to the reaction mixture and allowed for hydrogenation in the presence of hydrogen gas at 2 lbps pressure and stirred continuously for 15 hours. Once the reaction is completed, the reaction mixture is filtered and washed with ethyl acetate. The ethyl acetate is distilled off and crude mass is stirred with water to obtain a solid precipitate. Finally, the solid obtained is filtered and dried to pale brown crystals of white curcumin. White curcumin is encapsulated with beta-cyclodextrin, which exhibited increased bioavailability. White curcumin also exhibited anti-oxidant and chemopreventive activities.
机译:本发明公开了一种由纯化的姜黄素制备白姜黄素的方法。姜黄素通过溶剂提取和干燥姜黄粉的结晶获得。向高压釜中加入乙酸乙酯,并将95%纯度的姜黄素混合物加入并在室温下搅拌均匀。将5%(w / w)的10%钯碳加入到反应混合物中,并在氢气存在下在2lbps压力下氢化,并连续搅拌15小时。一旦反应完成,将反应混合物过滤并用乙酸乙酯洗涤。蒸馏出乙酸乙酯,并将粗物质与水一起搅拌以获得固体沉淀物。最后,将获得的固体过滤并干燥成白色姜黄素的浅棕色晶体。白姜黄素被β-环糊精包裹,后者具有更高的生物利用度。白姜黄素还表现出抗氧化和化学预防活性。

著录项

  • 公开/公告号EP3233068A1

    专利类型

  • 公开/公告日2017-10-25

    原文格式PDF

  • 申请/专利权人 AUREA BIOLABS PRIVATE LIMITED;

    申请/专利号EP20150869430

  • 发明设计人 GOPI SREERAJ;JACOB JOBY;GEORGE ROBIN;

    申请日2015-12-04

  • 分类号A61K31/045;A61K31/05;C07C57/42;C07C57/72;C07C209/26;

  • 国家 EP

  • 入库时间 2022-08-21 14:04:55

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