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EARLY DEVELOPMENTAL GENOMIC ASSAY FOR CHARACTERIZING PLURIPOTENT STEM CELL UTILITY AND SAFETY
EARLY DEVELOPMENTAL GENOMIC ASSAY FOR CHARACTERIZING PLURIPOTENT STEM CELL UTILITY AND SAFETY
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机译:早期鉴定基因组干细胞的实用性和安全性的基因组检测
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摘要
The present invention generally relates to a set of early developmental reference data or lineage scorecard for stem cells, and methods, systems and kits to generate a lineage scorecard for predicting the functionality and suitability of stem cell lines. In some aspects, methods for generating a scorecard comprises measuring the gene expression of a plurality of early developmental genes, such as pluripotent, early ectoderm, early mesoderm and early endoderm genes to predict the pluripotency and differentiation potential of the stem cell line and its functionality and/or suitability for a desired use. In some embodiments, a reference scorecard can be compared with the test stem cell line scorecard to accurately predict the utility and/or identify specific characteristics of the stem cell line, e.g., to determine its suitability for downstream applications, e.g., therapeutic use, drug screening, toxicity assays, differentiation into a desired cell lineage, etc.
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