PURIFICATION OF TRIPHOSPHORYLATED OLIGONUCLEOTIDES USING CAPTURE TAGS AND MODIFIED TRIPHOSPHORYLATED OLIGONUCLEOTIDES AS ACTIVATORS OF RIG-1 HELICASE

摘要

The present invention relates to a method of preparing triphosphate-modified oligonucleotides using a capture tag. The method allows the synthesis and purification of triphosphate-modified oligonucleotides in high yield and purity suitable for pharmaceutical applications.