COMPOSITION AND METHOD FOR THERAPEUTIC USE OF ATONAL-ASSOCIATED SEQUENCE FOR DEAFNESS, OSTEOARTHRITIS AND ABNORMAL CELL PROLIFERATION

摘要

PROBLEM TO BE SOLVED: To provide characterization and use of an atonal-associated nucleic acid or amino acid sequence, or any of its homologs or orthologs, as a therapeutic agent for the treatment of deafness, partial hearing loss, vestibular defects due to damage or loss inner ear hair cells, osteoarthritis, and abnormal cell proliferation.SOLUTION: A composition contains an atonal-associated amino acid sequence or a nucleic acid sequence for promoting mechanical recipient cell proliferation of a therapeutic inner ear in an animal. The atonal-associated amino acid sequence has polypeptide having at least about 80% identity to the sequence AANARERRRMHGLNHAFDQLR, or the atonal-associated nucleic acid sequence encodes the polypeptide having at least about 80% identity to the sequence AANARERRRMHGLNHAFDQLR.SELECTED DRAWING: None