PYRAZOLE CARBOXAMIDE DERIVATIVES AS TAAR REGULATOR FOR USE IN TREATMENT OF SEVERAL DISORDERS SUCH AS DEPRESSION, DIABETES AND PARKINSON'S DISEASE

摘要

PROBLEM TO BE SOLVED: To provide pyrazole carboxamide derivatives as a trace amine associated receptor (TAAR) regulator that may be used for treatment of depression, anxiety disorder, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorder, psychotic disorder such as schizophrenia, and neurological disease such as Parkinson's disease.SOLUTION: The problem is solved by a compound represented by formula (I) or a pharmaceutically suitable acid addition salt thereof. [Z is a bond, CHor O; Ris halogen, cyano, substituted/unsubstituted alkyl, cycloalkyl, substituted/unsubstituted phenyl, or the like; Ris H or alkyl; and Ris H, amino, or alkyl.]SELECTED DRAWING: None